NewsNation Prime is the weekend evening newscast of NewsNation, the Nexstar-owned cable news network. It airs Saturdays and Sundays beginning at 7 p.m. Eastern, and the network describes it as "America's source for unbiased news offering a full range of perspectives from across the U.S." Since June 2026 it has been anchored by Hena Doba, who succeeded Natasha Zouves, with Jessica Kartalija also hosting some editions. Its coverage of unidentified anomalous phenomena has been occasional.

The program dates to the network's beginnings. It premiered on September 1, 2020, as a three-hour primetime newscast broadcast live from WGN's studios in Chicago, replacing the entertainment programming that had filled WGN America's evenings, and it was the first step in Nexstar's conversion of the channel into NewsNation. On September 22, 2020, anchor Joe Donlon interviewed President Trump; the first hour peaked at 218,000 viewers before the audience fell to 54,000 in the third hour.

As NewsNation shifted toward personality-led programs, the newscast shrank. In 2021 NewsNation cut it to two hours, giving the former final hour to Ashleigh Banfield's new show, and on October 3, 2022, CUOMO replaced it on weeknights. It has aired only on weekends since then, with Zouves anchoring from 7 to 10 p.m. in the network's 2024 round-the-clock schedule.

The weekend program is a rolling newscast of politics, crime and breaking stories. Its autumn 2026 editions covered the midterm Senate races, the war with Iran, a foiled terror plot at RAF Fairford in England, a suspected pneumonic plague outbreak in Russia, AI agents that accessed government websites and the reopened Cornell University sexual assault case.

UAP stories appear only now and then, usually through NewsNation's own UAP specialists. In August 2026 correspondent Ross Coulthart discussed a Soviet-era investigation into a metallic object found under a garden in a Tallinn suburb in 1969. After the Pentagon's September file release, Harvard astrophysicist Avi Loeb said he was puzzled that objects described in a 1952 Project Blue Book briefing by Capt. Edward J. Ruppelt moved at up to five times the speed of sound without making any sound, and Coulthart said heavy redactions meant "good science can't be done." These were a handful among dozens of general news segments, which makes the program a minor venue for the subject compared with the network's weekday evening shows.